Global brokerage firm Jefferies shared their top 28 US stocks in the “highest-conviction Buy rated” stocks.
Jefferies shared the list as the US market is coming fresh off its best month in May since November 2023.
After three consecutive months of decline from February to April, in May, the S&P 500 recorded a 6.15% gain.
Jefferies said their 28 stocks “are underpinned by differentiated analysis, supported by catalysts and sit at valuation levels that suggest upside.”
Here are some of their main stock ideas:
Nvidia
The AI darling Nvidia (NVDA) was among the top picks of Jefferies. The brokerage firm has set a price target of $185, indicating a 31% upside from current levels.
Jefferies was bullish on Nvidia due to the company ramping up the Blackwell ultra chips and expects the margins to improve to mid-70 % throughout the year.
“We view NVDA as the dominant supplier of AI accelerators within the data center, an industry that is expanding rapidly due to the development and adoption of AI,” the brokerage added.
Nvidia shares are up 2% in the year so far.
DexCom
Dexcom (DXCM), the healthcare company, was also among Jefferies’ picks. The brokerage gave the glucose monitoring systems maker a price target of $110, which implies a 27% upside.
Jefferies expects DXCM to capitalise on a top revenue driver as it plans to expand coverage to Type 2 non-insulin (NIT2) patients.
Dexcom recently received approval from the US Food and Drug Administration for its 15-day glucose monitoring sensor. The brokerage notes that the conversion to 15-day sensors could drive the company’s margins significantly.
Dexcom stock has nearly gained 10% year to date.
Capital One
Jefferies also picked Capital One (COF) in the list. The brokerage firm gave a $230 target, which is an 18% upside from the previous market close.
It sees the company’s recent acquisition of Discover Financial Services as a major catalyst.
“Merger with DFS has been completed, unlocking significant network and OPEX synergies,” Jefferies wrote.
The brokerage firm also expects the improving credit card trends among Capital One and Discover’s books to lead to boosted profitability through wider net interest margins and the release of previously held reserves.
Capital One’s shares have risen over 8% in 2025 so far.
Other picks
The other stocks featured in the list, along with their price targets and expected upside, are:
All State (ALL)- price target: $260, 23% upside from previous market close. The stock has gained 9% in year to date.
Argenx (ARGX)- price target: $772, 33% upside from the previous market close. The stock plunged 6% in the year.
Caterpillar (CAT)- price target: $425, a 21% upside. The stock fell 2% in 2025.
Corpay (CPAY)- price target: $375, a 15% upside from the previous closing price. CPAY shares declined 3% in 2025.
DraftKings (DKNG) – Price target: $60, indicates a 74% upside. The shares fell 5% in the year.
EPAM Systems (EPAM) – Price target: $225, a 29% upside. EPAM stock plunged 23% in the year.
Equitable (EQH) – Price target: $66, a 23% upside from the previous closing price. The shares gained over 11% in 2025.
Expand Energy (EXE) – Price target: $135, a 14% upside, the stock surged 14% in the year.
Flowserve (FLS) – Price target: $65, a 28% upside. The stock has plunged 15% in the year.
GE Healthcare (GEHC) – Price target: $95, a 33% upside. The stock has fallen 9% in the year.
GFL Environmental (GFL) – Price target: $60, a 21.6% upside. The stock has plunged 30% in the year.
Gilead (GILD) – Price target: $130, 18.9% upside. The stock has gained 19% in the year.
Huntington Bancshares (HBAN) – Price target: $20, a 25.7% upside. The stock has fallen 2.75% in the year.
International Flavors & Fragrances (IFF) – Price target: $89, a 16.1% upside. The stock has fallen 6.11% in the year.
International Paper (IP) – Price target: $65, a 37.7% upside. The stock has fallen 10.74% in the year.
Kenvue (KVUE) – Price target: $27, a 21.5% upside. The stock has gained 3.27% in the year.
Martin Marietta Materials (MLM) – Price target: $610, a 11.8% upside. The stock has gained 8% in the year.
Microsoft (MSFT) – Price target: $550, a 18.7% upside. The stock has gained 10% in the year.
Performance Food Group (PFGC) – Price target: $102, a 14.8% upside. The stock has gained 5% in the year.
PVH (PVH) – Price target: $105, a 27.3% upside. The stock has fallen 22% in the year.
Saia (SAIA) – Price target: $350, a 30.7% upside. The stock has fallen 40% in the year.
TransDigm (TDG) – Price target: $1,600, a 9.9% upside. The stock has surged 16% in the year.
TKO (TKO) – Price target: $220, a 34.9% upside. The stock has surged 16% in the year.
UGI (UGI) – Price target: $38, a 4.8% upside. The stock has surged 27% in the year.
Ventas (VTR) – Price target: $83, a 31.2% upside. The stock has surged 9% in the year.
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